Pesquisa | Portal de Pesquisa da BVS

1.

Christian Raetz: scientist and friend extraordinaire.

Dowhan, William; Nikaido, Hiroshi; Stubbe, JoAnne; Kozarich, John W; Wickner, William T; Russell, David W; Garrett, Teresa A; Brozek, Kathryn; Modrich, Paul.

Annu Rev Biochem ; 82: 1-24, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-23472605

2.

The biochemistry of disease: desperately seeking syzygy.

Kozarich, John W.

Annu Rev Biochem ; 78: 55-63, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19489721

3.

Welcome to Biochemistry Volume 1: No Hyphen Required.

Kozarich, John W.

Biochemistry ; 60(46): 3427-3428, 2021 11 23.

Artigo em Inglês | MEDLINE | ID: mdl-34738805

4.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

Okerberg, Eric S; Dagbay, Kevin B; Green, Jennifer L; Soni, Ishankumar; Aban, Arwin; Nomanbhoy, Tyzoon K; Savinov, Sergey N; Hardy, Jeanne A; Kozarich, John W.

Biochemistry ; 58(52): 5320-5328, 2019 12 31.

Artigo em Inglês | MEDLINE | ID: mdl-31095371

5.

ERK5 kinase activity is dispensable for cellular immune response and proliferation.

Lin, Emme C K; Amantea, Christopher M; Nomanbhoy, Tyzoon K; Weissig, Helge; Ishiyama, Junichi; Hu, Yi; Sidique, Shyama; Li, Bei; Kozarich, John W; Rosenblum, Jonathan S.

Proc Natl Acad Sci U S A ; 113(42): 11865-11870, 2016 10 18.

Artigo em Inglês | MEDLINE | ID: mdl-27679845

6.

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.

Nomanbhoy, Tyzoon K; Sharma, Geeta; Brown, Heidi; Wu, Jiangyue; Aban, Arwin; Vogeti, Subha; Alemayehu, Senait; Sykes, Maria; Rosenblum, Jonathan S; Kozarich, John W.

Biochemistry ; 55(38): 5434-41, 2016 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-27571378

7.

ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.

Nordin, Brian E; Liu, Yongsheng; Aban, Arwin; Brown, Heidi E; Wu, Jiangyue; Hainley, Anna K; Rosenblum, Jonathan S; Nomanbhoy, Tyzoon K; Kozarich, John W.

Biochemistry ; 54(19): 3024-36, 2015 May 19.

Artigo em Inglês | MEDLINE | ID: mdl-25905789

8.

Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe.

Okerberg, Eric S; Brown, Heidi E; Minimo, Lauro; Alemayehu, Senait; Rosenblum, Jonathan; Patricelli, Matt; Nomanbhoy, Tyzoon; Kozarich, John W.

J Am Chem Soc ; 136(12): 4664-9, 2014 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-24601623

9.

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.

Li, Bei; Cociorva, Oana M; Nomanbhoy, Tyzoon; Weissig, Helge; Li, Qiang; Nakamura, Kai; Liyanage, Marek; Zhang, Melissa C; Shih, Ann Y; Aban, Arwin; Hu, Yi; Cajica, Julia; Pham, Lan; Kozarich, John W; Shreder, Kevin R.

Bioorg Med Chem Lett ; 23(18): 5217-22, 2013 Sep 15.

Artigo em Inglês | MEDLINE | ID: mdl-23916259

10.

Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2.

Hu, Yi; Lin, Emme C K; Pham, Lan M; Cajica, Julia; Amantea, Christopher M; Okerberg, Eric; Brown, Heidi E; Fraser, Allister; Du, Lingling; Kohno, Yasushi; Ishiyama, Junichi; Kozarich, John W; Shreder, Kevin R.

Bioorg Med Chem Lett ; 23(5): 1553-6, 2013 Mar 01.

Artigo em Inglês | MEDLINE | ID: mdl-23333209

11.

Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).

Lin, Emme C K; Hu, Yi; Amantea, Christopher M; Pham, Lan M; Cajica, Julia; Okerberg, Eric; Brown, Heidi E; Fraser, Allister; Du, Lingling; Kohno, Yasushi; Ishiyama, Junichi; Kozarich, John W; Shreder, Kevin R.

Bioorg Med Chem Lett ; 22(2): 868-71, 2012 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-22217870

12.

6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency.

Li, Bei; Cociorva, Oana M; Nomanbhoy, Tyzoon; Li, Qiang; Nakamura, Kai; Nomura, Masahiro; Okada, Kyoko; Yumoto, Kazuhiro; Liyanage, Marek; Zhang, Melissa C; Aban, Arwin; Szardenings, Anna Katrin; Kozarich, John W; Kohno, Yasushi; Shreder, Kevin R.

Bioorg Med Chem Lett ; 22(2): 1005-8, 2012 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-22202172

13.

Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).

Shreder, Kevin R; Lin, Emme C K; Wu, Jiangyue; Cajica, Julia; Amantea, Christopher M; Hu, Yi; Okerberg, Eric; Brown, Heidi E; Pham, Lan M; Chung, De Michael; Fraser, Allister S; McGee, Ethel; Rosenblum, Jonathan S; Kozarich, John W.

Bioorg Med Chem Lett ; 22(17): 5748-51, 2012 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-22877630

14.

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß.

Cociorva, Oana M; Li, Bei; Nomanbhoy, Tyzoon; Li, Qiang; Nakamura, Ayako; Nakamura, Kai; Nomura, Masahiro; Okada, Kyoko; Seto, Shigeki; Yumoto, Kazuhiro; Liyanage, Marek; Zhang, Melissa C; Aban, Arwin; Leen, Brandon; Szardenings, Anna Katrin; Rosenblum, Jonathan S; Kozarich, John W; Kohno, Yasushi; Shreder, Kevin R.

Bioorg Med Chem Lett ; 21(19): 5948-51, 2011 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-21873061

15.

S28 peptidases: lessons from a seemingly 'dysfunctional' family of two.

Kozarich, John W.

BMC Biol ; 8: 87, 2010 Jun 28.

Artigo em Inglês | MEDLINE | ID: mdl-20598110

16.

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.

Shreder, Kevin R; Cajica, Julia; Du, Lingling; Fraser, Allister; Hu, Yi; Kohno, Yasushi; Lin, Emme C K; Liu, Steve J; Okerberg, Eric; Pham, Lan; Wu, Jiangyue; Kozarich, John W.

Bioorg Med Chem Lett ; 19(16): 4743-6, 2009 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-19577470

17.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

Zhu, Wen; Radadiya, Ashish; Bisson, Claudine; Wenzel, Sabine; Nordin, Brian E; Martínez-Márquez, Francisco; Imasaki, Tsuyoshi; Sedelnikova, Svetlana E; Coricello, Adriana; Baumann, Patrick; Berry, Alexandria H; Nomanbhoy, Tyzoon K; Kozarich, John W; Jin, Yi; Rice, David W; Takagi, Yuichiro; Richards, Nigel G J.

Commun Biol ; 2: 345, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31552298

18.

Erratum: Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

Zhu, Wen; Radadiya, Ashish; Bisson, Claudine; Wenzel, Sabine; Nordin, Brian E; Martínez-Márquez, Francisco; Imasaki, Tsuyoshi; Sedelnikova, Svetlana E; Coricello, Adriana; Baumann, Patrick; Berry, Alexandria H; Nomanbhoy, Tyzoon K; Kozarich, John W; Jin, Yi; Rice, David W; Takagi, Yuichiro; Richards, Nigel G J.

Commun Biol ; 2: 438, 2019.

Artigo em Inglês | MEDLINE | ID: mdl-31799439

19.

New LSD therapies unfolding.

Kozarich, John W.

Chem Biol ; 14(9): 976-7, 2007 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-17884629

20.

Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.

Liu, Yongsheng; Wu, Jiangyue; Weissig, Helge; Betancort, Juan M; Gai, Wen Zhi; Leventhal, Phillip S; Patricelli, Matthew P; Samii, Babak; Szardenings, Anna K; Shreder, Kevin R; Kozarich, John W.

Bioorg Med Chem Lett ; 18(22): 5955-8, 2008 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-18774710

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Christian Raetz: scientist and friend extraordinaire.

The biochemistry of disease: desperately seeking syzygy.

Welcome to Biochemistry Volume 1: No Hyphen Required.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

ERK5 kinase activity is dispensable for cellular immune response and proliferation.

Chemoproteomic Evaluation of Target Engagement by the Cyclin-Dependent Kinase 4 and 6 Inhibitor Palbociclib Correlates with Cancer Cell Response.

ATP Acyl Phosphate Reactivity Reveals Native Conformations of Hsp90 Paralogs and Inhibitor Target Engagement.

Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe.

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.

Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2.

Amides of xanthurenic acid as zinc-dependent inhibitors of Lp-PLA(2).

6-Position optimization of tricyclic 4-quinolone-based inhibitors of glycogen synthase kinase-3ß: discovery of nitrile derivatives with picomolar potency.

Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1).

Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3ß.

S28 peptidases: lessons from a seemingly 'dysfunctional' family of two.

Synthesis and optimization of 2-pyridin-3-yl-benzo[d][1,3]oxazin-4-one based inhibitors of human neutrophil elastase.

High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

Erratum: Author Correction: High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.

New LSD therapies unfolding.

Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta.